Zollinger-Ellison Syndrome

Zollinger-Ellison syndrome is a condition caused by abnormal production of the hormone gastrin. A small tumor (gastinoma) in the pancreas or small intestine produces the high levels of gastrin in the blood.

Causes, incidence and risk factors : Zollinger-Ellison syndrome is caused by tumors usually found in the head of pancreas and upper small bowel. These tumors produce the hormone gastrin and are called gastrinomas. High levels of gastrin cause overproduction of stomach acid. High stomach acid levels lead to multiple ulcers in the stomach and small bowel. Patients with Zollinger-Ellison syndrome may experience abdominal pain and diarrhea. The diagnosis is also suspected in patients without symptoms who have severe ulceration of the stomach and small bowel. Gastrinomas occur as single tumors or as small multiple tumors. About one-half to two-thirds of single gastrinomas are malignant tumors that commonly spread to the liver and nearby lymph nodes. Nearly 25% of patients with gastrinomas have multiple tumors as part of a condition called multiple endocrine neoplasia type I (MEN I). MEN I patients often have tumors of the pituitary gland (brain) and parathyroid (neck) glands in addition to tumors of the pancreas.

Symptoms   

•  Pain
•  Multiple ulcers in the stomach and small bowel
•  Vomiting blood (occasional)
•  Diarrhea

Role of Noni

Noni contains all the vitamins like vitamin A , vitamin B complex, vitamin C, vitamin E. It contains all the trace minerals. A number of major components are identified in the Noni plant like scopoletin, octoanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones (such as nordamnacanthal, morindone, rubiadin, and rubiadin-1-methyl ether, anthraquinone glycoside), sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, Alizarin, amino acids, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin and a putative proxeronine.

Antioxidant property of Noni : Noni blocks the oxidative damage that is one of the important factors of ulcer aggravation and base line causes of tumor formation. Noni acts like an effective and powerful antioxidant.

Endogenous antioxidants and role of Noni : Our body has evolved with endogenous defense mechanisms to protect against free radical induced cell damage. Glutathione peroxidase, catalase and Superoxide dismutases are three primary antioxidant enzymes in our body, which involved in direct elimination of free radicals or reactive oxygen species from our body. They require micronutrients like selenium, iron, copper, zinc and manganese as cofactors for their formation and optimum catalytic and effective antioxidant activity. Noni contains all the trace minerals that help for optimum catalytic activity of those three important antioxidant enzymes for an effective antioxidant defense mechanism.

Glutathione, ascorbic acid, alpha-tocopherol, beta-carotene, bilirubin, selenium, dihydrolipoic acid, reduced CoQ10, melatonin, uric acid etc., as a whole play a homoeostatic or protective role against ROS produced during normal cellular metabolism and after active oxidation insult. Noni contains all the above phyto chemicals and vitamins in abundant quantity. Glutathione (GSH) is the most significant component which directly quenches Reactive Oxygen Species (ROS) such as lipid peroxides and plays major role in xenobiotic metabolism. Glutathione is a tripeptide made up of amino acids gamma-glutamic acid, cysteine and glycine. Noni contains all those glutathione making amino acids in abundant number. Noni increases the body’s glutathione level. Noni stimulates more melatonin secretion from the pineal body.  It also maintains ascorbate (vitamin C) and alpha-tocopherol (vitamin E), in their reduced form, which also exert an antioxidant effect by quenching free radicals.

Exogenous antioxidants : Contribution from Noni

A number of other dietary antioxidants known as phytonutrients or phytochemicals that are being increasingly appreciated for their antioxidant activity. One example is flavonoids which are a group of polyphenolic compounds. They are responsible for the different brilliant colors such as blue, scarlet, and orange.  Noni  contains 150 and above phytochemicals including all flavonoids. Flavonoids exhibit several biological effects like antitumoural, anti-ischaemic, anti-allergic, anti-hepatotoxic, anti-ulcerative and anti inflammatory activities. These are also known to inhibit the activities of several bad enzymes like lipoxygenase, cyclooxygenase, monooxygenase, xanthine oxidase, glutathione-S transferase, mitochondrial succino-oxidase and protein kinases. Many of the biological activities of flavonoids are attributed to their antioxidant properties and free radical scavenging capabilities. Noni is rich in many flavonoids. Noni also helps for the apoptosis of tumor.                                                                                                                                         

Recommended Dosage

Divine Noni Concentrate

5ml morning and 5ml evening for 3 days. Then

10ml morning and 10ml evening for next 3 days. Then

15ml morning and 15ml evening for next 8 months.