Raynaud’s Syndrome
Raynaud’s syndrome (RS) can be a debilitating condition that causes periods of severely restricted blood flow to the fingers and toes (and sometimes to other parts of the body such as the nose or ears). In the worst case scenario, this results in amputation of damaged digits.
RS typically affects the small blood vessels in fingers and toes but affects those in the ears, nose and tip of the tongue as well. During episodes of RS, the affected area becomes painful and turns blue.
In individuals with RS, the normal reaction is exaggerated—blood circulation in the arterioles is greatly restricted, resulting in a visible progression of symptoms as blood flow to the affected areas drops. Skin first turns white as it is deprived of blood, then turns blue (cyanosis) because of the lack of blood and oxygen and then has localized red flushing as the blood returns to the affected area. This progression may be accompanied at first by a loss of sensation in the affected extremities, followed by a prickling, throbbing, or tingling sensation as circulation returns.
Skin changes may migrate, moving from one finger to the next, sometimes even involving the thumb.
Role of Noni
Vasodilator and Noni : In normal healthy tissue, blood flows to the skin is regulated by a complex system that includes neural signals, hormones and mediators released from circulating cells and blood vessels. Under normal circumstances, when a person is exposed to cold or is under emotional stress, arterioles constrict to return blood flow to the core of the body, for warmth and protection. This reaction is regulated by vasoconstrictive agents such as endothelin 1 and factors that impair production of nitric oxide, a potent vasodilator. Noni stimulates secretion of more nitric oxide in our body. It also contains many ingredients like scopoletin, flavonoid groups which have potent vasodilator effect.
The RS causes significant free radical nerve damage in the affected tissues. This damage leads to local endothelial dysfunction, thickening of the arterial walls and the formation of scar tissue, or fibrosis. The levels of important antioxidants are depleted in patients who have RS.
Antioxidant property of Noni
In each case, RS may contribute to the more serious disease by encouraging formation of scar tissue in the connective tissue and through damage to arteries. Therefore, it is crucial that patients who have RS pursue aggressive antioxidant therapy to lower their risk of developing a more serious condition.
Noni is an effective and powerful antioxidant. Noni contains all the antioxidant vitamins like vitamin C, Vitamin E and beta-carotene. It also contains many trace elements having antioxidant property too. Besides that Noni contains 150 and above phytochemicals or nutraceuticals, which have an effective antioxidant property. Noni also stimulates the endogenous antioxidant system of the body. It enhances secretion of three important antioxidant enzymes- glutathione peroxidase, super oxide dismutase and catalase in our body.
Vitamin E : Vitamin E is a key antioxidant, protecting polyunsaturated fatty acids from oxidation. Noni contains vitamin E including all antioxidant vitamins.
Vitamin C : Vitamin C is important for the synthesis of collagen, a key component of blood vessel walls. Noni is rich with vitamin C. Studies demonstrated that administering vitamin C improves blood flow. In patients, who have atherosclerosis of the coronary arteries, the ascorbic acid form of vitamin C improved blood vessel vasoconstriction, thus improving blood flow through the arteries.
Niacin : An experimental evaluation of usefulness of no-flush niacin in treating RS concluded that it produced beneficial therapeutic effects on microcirculation, not only through vasodilatation, but also through mechanisms like an enhanced ability to break up clots (fibrinolysis) and lowering of lipids (fats) in the blood. Noni contains this B complex group vitamins in natural form
Magnesium : Magnesium is essential to maintain relaxation of smooth muscle of small arteries affected by RS. Magnesium levels were significantly lower in winter than in summer. Supplementation with Noni to RS patient increases the magnesium level as Noni contains 3 to 12 mg of magnesium in 100 g of it.
Essential Fatty Acids : Essential fatty acids are anti-inflammatories that help relieve symptoms of RS. Noni contains all essential fatty acids.
L-Arginine : L-arginine reverses tissue damage caused by RS and improves symptoms in subsequent attacks . It stimulates production of nitric oxide, thus helping to keep arteries open and relaxed. Noni contains rich amount of this amino acids arginine.
Recommended Dosage
Divine Noni Concentrate
5ml morning and 5ml evening for 3 days. Then
10ml morning and 10ml evening for next 3 days. Then
15ml morning and 15ml evening for next 8 months.
