Poliomyelitis

Poliomyelitis is a disorder caused by a viral infection (poliovirus) that can affect the whole body including muscles and nerves. Severe cases may cause permanent paralysis or death. There are three basic patterns of polio infection, subclinical infections, nonparalytic and paralytic. Approximately 95% of these are subclinical infections, which may go unnoticed. Clinical poliomyelitis affects the central nervous system (brain and spinal cord) and is divided into nonparalytic and paralytic forms. It occurs after recovery from a subclinical infection.

Subclinical Infection

•  No symptoms, or symptoms lasting 72 hours or less
•  Slight fever
•  Headache
•  General discomfort or uneasiness (malaise)
•  Sore throat
•  Red throat
•  Vomiting

Nonparalytic Poliomyelitis

•  Symptoms last 1 to 2 weeks
•  Moderate fever
•  Headache
•  Vomiting
•  Diarrhea
•  Excessive tiredness, fatigue
•  Irritability
•  Pain or stiffness of the back, arms, legs, abdomen
•  Muscle tenderness and spasm in any area of the body
•  Neck pain and stiffness
•  Pain front part of neck
•  Back pain or backache
•  Leg pain (calf muscles)
•  Skin rash or lesion with pain
•  Muscle stiffness
•  Paralytic Poliomyelitis
•  Fever, occurring 5 to 7 days before other symptoms
•  Headache
•  Stiff neck and back
•  Muscle weakness, asymmetrical (only on one side or worse on one side)
•  Rapid onset
•  Progresses to paralysis
•  Location depends on where the spinal cord is affected
•  Abnormal sensations (but not loss of sensation) of an area
•  Sensitivity to touch, mild touch may be painful
•  Difficulty beginning to urinate
•  Constipation
•  Bloated feeling of abdomen
•  Swallowing difficulty
•  Muscle pain
•  Muscle contractions or muscle spasms, particularly in the calf, neck, or back
•  Drooling
•  Breathing difficulty
•  Irritability or poor temper control
•  Positive Babinski’s reflex

Goal of treatment is to control symptoms while the infection runs its course. Symptoms are treated according to their presence and severity. Pain like headache, muscle pain, and spasms should be checked in all parts of the patients body. Moist heat (heating pads, warm towels, etc.) reduces muscle pain and spasm.

Pathophysiology

Acute poliomyelitis is caused by small ribonucleic acid (RNA) viruses of the enterovirus group of the picornavirus family. The single-stranded RNA core is surrounded by a protein capsid without a lipid envelope, which makes poliovirus resistant to lipid solvents and stable at low pH. Three antigenically distinct strains are known, with type I accounting for 85% of cases of paralytic illnesses. Infection with one type does not protect from the other types; however, immunity to each of the 3 strains is lifelong.

The enteroviruses of poliomyelitis infect the human intestinal tract mainly through the fecal-oral route (hand to mouth). The viruses multiply in the pharynx and lower gastrointestinal tract during the first 1-3 weeks of the incubation period.

The poliovirus disseminates along neural pathways and causes nervous system infection by involving the precentral gyrus, thalamus, hypothalamus, motor nuclei of the brainstem and surrounding reticular formation, vestibular and cerebellar nuclei and neurons of the anterior and intermediate columns of the spinal cord. The nerve cells undergo central chromatolysis along with an inflammatory reaction while multiplication of the virus preceedes onset of paralysis. As the chromatolysis process goes on further, muscle paralysis or even atrophy appears when fewer than 10% of neurons survive in the corresponding cord segments. Gliosis develops when the inflammatory infiltrate has subsided, but most surviving neurons show full recovery.

Role of Noni in Poliomyelitis

Noni helps to reduce muscular pain in poliomyelitis pain and inflammation and follow the release of prostaglandins. Aspirin and similar non-steroidal anti-inflammatory drugs (NSAIDS) reduce prostaglandins by blocking an enzyme which helps to produce them, called  cyclooxygenase (COX).There are actually two COX enzymes in the body. They are COX-1 and COX-2. COX-1 is called the good COX enzyme, while COX-2 earned the unflattering name as the bad enzyme. COX1 is easily identifiable and is important in regulating cell function. COX2, on the other hand, is generally undetectable in most tissues, but increases to high levels during acute inflammation. The COX2 enzyme is largely responsible for causing pain and inflammation. Injury, disease and trauma cause COX2 enzyme to produce prostaglandins, which cause pain and inflammation. In contrast to the COX-2 enzyme, COX-1 enzyme is responsible for protecting the body’s stomach lining and kidneys. COX-1 enzymes continually produce protective prostaglandins.

Role of Noni

Studies in mice have demonstrated that extracts from the root of Noni (again, not rendered from the fruit) have some pain relieving and sedative activity. Noni is a selective COX-2 inhibitor Researchers  found that indeed Noni was a selective inhibitor of COX-2 enzyme. In addition, the Noni does not damage the COX1 enzyme. Another reason for Noni’s pain fighting qualities may stem from several of its constituents. Noni contains scopoletin, which has anti inflammatory effects. Scopoletin is needed in the body for smooth joint movement. It also produces anti-histamine effects. A laboratory in France conducted a study that showed mice, given a liquid form of Noni, increased pain tolerance as reflected by their reaction time to a hot plate. The researchers concluded that Noni helped the mice better to deal with pain from the hot plate.

Role of Noni in Chromatolysis of central neurons in case of Poliomyelitis

NONI works as a healthy, immune system promoter. Current studies revealed that NONI  helps prompting a healthy immune system by either enhancing an already functioning system or by stimulating a sluggish one. Noni the super natural nutritional supplement, keeps your immune system active. Keep in mind that your body is an excellent self-healing machine. And what fuels it? Nutrition. Noni plays the role of correcting the chromatolysis  of central neurons in polio by its property of high immune modulating activity.

Noni Promotes The Cellular Growth

In addition to the antioxidant activity in Noni, Dr. Ralph Heinicke, Ph.D., pinpointed constituents in Noni that he believed responsible for the Juice’s ability to promote cellular growth. These are parts of his postulated xeronine system, which consists of proxeronine, proxeroninease and xeronine. The xeronine theory, which is based on much of Dr.Heinicke’s work, postualates that once in the body, proxeronine travels to specific parts of cells, like the mitochondria, microsomes, Golgiapparatus, reticuloendothelium, electron transport system, DNA, RNA and etc. Within the cell, these components communicate with each other (intracellular) and with other cells (intercellular).

Recommended Dosage

Divine Noni Concentrate

5ml morning and 5ml evening for 3 days. Then

10ml morning and 10ml evening for next 3 days. Then

15ml morning and 15ml evening for next 8 months.