Pain and COX Enzymes

People suffer from pain and inflammation which turn even the simplest task into a major challenge. This chronic pain and inflammation, often associated with arthritis, are found frequently in the elderly and especially in women. Men and women of all ages were diagnosed with the condition, and it seems the numbers are rising. More and more people with chronic pain and inflammation courageously live active lives, seeking treatment to relieve the pain associated with their condition.

Unfortunately, as with many other chronic illnesses, treatment for chronic pain and inflammation is not always successful or free of long-term risks and the medications available to help with these symptoms can cause negative side effects. But recent research uncovered some long-awaited findings pointing to a more reliable, safer method for treating chronic pain and inflammation over long periods of time. Scientific studies reported in several medical journals have touted the revolutionary concept of COX-2 enzymatic inhibition.

COX Enzymes

Scientists originally believed that all COX enzymes within the body were the same. Only recently they discovered that there was actually two COX enzymes: COX-1 and COX-2. Research shows that in the body, the COX-2 enzyme is largely responsible for causing pain and inflammation. Injury, disease and trauma cause COX-2 enzymes to produce prostaglandins, which cause pain and inflammation. In contrast to the COX-2 enzyme, the COX-1 enzyme is responsible for protecting the body’s stomach lining and kidneys. COX-1 enzymes continually produce protective prostaglandins.

When taken, over long period of time, traditional medication for chronic pain and inflammation, such as aspirin and nonsteroidal anti-inflammatories (NSAIDs) like Ibuprofen inhibit both COX-1 and COX-2 enzymatic activity. This inhibition of the COX-2 enzyme reduces the prostaglandins that cause pain and inflammation throughout the body, but over time, it also restrains the COX-1 enzyme from producing the prostaglandins that protect the stomach lining. This can result in major problems, such as ulcers and colitis, in the body’s digestive system.

Noni’s Connection with selective COX-2 inhibition

The discovery of COX-2 created a frenzy in the pharmaceutical world- everyone wanted to find a substance that would inhibit COX-2 without harming the body’s production of COX-1. Exciting scientific findings from carefully conducted research done in an independent laboratory show that Noni inhibits the COX 2 enzyme selectively while allowing the COX-1 enzyme to continue functioning.

The best news for chronic pain sufferers is that the non-observable adverse effects of Noni are thousands of times better than that of the leading prescription drugs for chronic pain and arthritis. Some of these prescription drugs have negative side effects like rashes, facial swelling, unusual bleeding and stomach pain. In contrast, preclinical safety studies show that long-term use of Noni is not a problem, unlike the problematic long-term use of aspirin and N-SAIDs. In fact, one study conducted in Los Angels reported that nearly 30% of those people who daily used Ibuprofen developed ulcers.

COX-2 and other conditions : The discovery of the COX-2 enzyme helps conditions other than chronic pain and inflammation. A few scientists believe that a selective COX-2 inhibitor could help with menstrual pain and help prevent cancers of the colon, oesophagus, skin, and bladder. Even those who have been diagnosed with Alzheimer’s may benefit from a selective COX-2 inhibitor.

The Blessing of Noni

It is no surprise to anyone acquainted with Noni to learn that this natural product has been found to inhibit the effects of the COX-2 enzyme selectively. In fact, for thousands of years, stories about the blessings this fruit has brought into the lives of those who have used it have circulated around. The fact that Noni inhibits COX 2 enzyme is just one of the recent scientific findings confirming the traditional use of noni as a natural healer. Scientists continue to uncover more about the human body, revealing the phenomenal benefits of Noni to the world.

Recommended Dosage

Divine Noni Concentrate

5ml morning and 5ml evening for 3 days. Then

10ml morning and 10ml evening for next 3 days. Then

15ml morning and 15ml evening for next 8 months.