Malignant Teratoma
Malignant teratoma is a type of cancer that involves cysts that contain one or more of the three main types of cells found in a developing baby (embryo). These cells are called ectoderms, mesoderms and endoderms.
Causes, Incidence, and Risk factors
Malignant teratoma occurs most often in young men in their 20 - 30’s. It is often located in the anterior mediastinum (in the chest). Most malignant teratomas have spread (metastasized) by the time of diagnosis and they can spread throughout the body.
A number of other cancers are often associated with these tumors including
- Acute myelogenous leukemia (AML)
- Myelodysplasia (MDS)
- Malignant histiocytosis
- Embryonal rhabdomyosarcoma
- Small cell undifferentiated carcinoma
Symptoms
Symptoms result from spread of the tumor into surrounding tissues and include :
- Cough
- Shortness of breath
- Chest pain
- Limited exercise tolerance
- Fatigue
Role of Noni
Noni contains all the vitamins like vitamin A, vitamin B complex, vitamin C and vitamin E. It contains all the trace minerals. A number of major components are identified in the Noni plant such as scopoletin, octoanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones (such as nordamnacanthal, morindone, rubiadin, and rubiadin-1-methyl ether, anthraquinone glycoside), sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, Alizarin, amino acids, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin and a putative proxeronine.
Noni ppt (The polysaccharide) is a unique polysaccharide used as a chemo-immunotherapy agent to treat cancer. NONI-ppt present in NONI develop an anti-tumor response by stimulating the release of various cytokines mediator of the immune system of our body like
- Interleukin
- Interferon – gamma
- Nitric oxide
- Tumour necrosis factor
- Natural killer cells
They help for controlling carcinogenesis by inhibiting growth and mutation of malignant cells.
Pretreatment with Noni followed by ultraviolet irradiation increased the levels of phosphorylated extra cellular signal-regulated kinases (ERK) and stress-activated protein kinases (SAPK) enzymes in the body. Activation of SARK and ERKs play an important role in triggering apoptosis. Thus their activation proves stimulatory effect of Noni on ultraviolet-induced apoptosis. Noni exhibits antiangiogenesis effects on the malignant cells.
The cancer tumor has the ability to develop its own blood vessels around it to get their nutrition for growth by the process of angiogenesis. Many phytochemicals present in NONI like Damnacanthal, Alizarin, Limonene, Epigallocatechin gallate (EGCg) etc, just a few among the 150+ phytochemicals present in Noni that exhibit ANTIANGIOGENESIS effect on the malignant cells. Thus it inhibits the growth and mutations of malignant cells and induces program cell death or apoptosis.
Epigallocatechin gallate (EGCg)
EGCg is a polyphenolic flavonoids antioxidant, found in abundance in Noni. EGCg in Noni inhibits the quinol oxidase (NOX) enzyme tumor activity property thus helps in antiangiogenesis.
NOX enzymes are found in a variety of cell types and tissues where they react with oxygen to generate reactive oxygen species (ROS), the free radical forms of oxygen that damage the DNA of cell.
The ROS is involved in mutations and tissue damage in diseases like cancer and rheumatoid arthritis. Normal amounts of NOX production are important to regulate cell growth. It is generally inactive during the normal cell division process on response to growth hormone stimulation but it is active in all the time in cancerous cell and responsible for the cancerous cell proliferation, cell motility, invasion and angiogenesis process, all of them prerequisites for tumor metastasis.
EGCg, a primary component of NONI inhibits the NOX activity of cancer cells. According to Dr. Morre’s experimental studies, it is found that EGCg in NONI inhibits NOX carcinogenesis activity but does not inhibit the NOX activity of healthy cells. Noni prevents the carcinogen DNA adduct formation on cell.
Most chemical carcinogens need activation by our body enzymes to be transformed to an ultimate form that readily binds to genetic DNA to form DNA adducts. Carcinogen DNA adducts formation causes DNA damage. Carcinogen DNA adducts can be repaired by body enzymes. The unprepared DNA damaged cell will be responsible for mutation and the consequent cancer development. Therefore preventing carcinogen-DNA adduct formation is a key step for primary prevention in cancer at the initiation step of carcinogenesis. Noni helps in prevention or block the formation of carcinogen induced DNA adduct. Hence it may prevent cancer at the initiation stage of carcinogenesis.
Role of Antioxidants in Cancer Prevention
Oxidative stress in our body is the underlying cause of cancer. When excessive free radicals are allowed to exist near the nucleus of cell, significant damage to the DNA of cell results. Free radicals can also wreck damage on genetic structure of DNA, which can then lead to abnormal growth of cell. As these cells continue to replicate, this mutated DNA is carried to each newly developed cell. When there is further oxidative stress to this mutated DNA of the cell, more damage occurs. The cell will then begin to grow out of control. It spreads from one part of the body to other(metastasis), thus becoming a true cancer
Oxidative stress is indeed the cause of cancer, antioxidants used to bring free radical back into balance would lower the risk of cancer. Therefore, the best strategy is to maximize our own body’s immune system and antioxidant defense and this begins by eating a healthy natural suppliment rich with antioxidants. Noni is the rich source of antioxidants. The high anti oxidant property of Noni helps to prevent the formation of carcinogen-DNA adducts. It was hypothesized that the antioxidants in Noni may have cancer protective effects by scavenging reactive oxygen free radicals and quenching lipid peroxides.
Recommended Dosage
Divine Noni Concentrate
5ml morning and 5ml evening for 3 days. Then
10ml morning and 10ml evening for next 3 days. Then
15ml morning and 15ml evening for next 8 months.
