Kidney diseases

Chronic Renal Failure (CRF) is the progressive loss of kidney function. The kidneys attempt to compensate for renal damage by hyper filtration (excessive straining of the blood) within the remaining functional nephrons (filtering units that consist of a glomerulus and corresponding tubule). Over time, hyperfiltration causes further loss of function.

Chronic loss of function causes generalized wasting (shrinking in size) and progressive scarring within all parts of kidneys. In time, overall scarring obscures the site of initial damage. Yet, it is not until over 70% of normal combined function of both kidneys is lost that most patients experience symptoms of kidney failure.

Causes

The cause(s) of CRF sometimes can be determined by a detailed medical history, a comprehensive physical examination, and laboratory studies. More often than not, determining the cause of CRF is difficult if not impossible. Even a kidney biopsy may be inconclusive, because all forms of kidney failure eventually progress to diffuse scarring and look the same on kidney biopsy.

Pre-Renal CRF

Some medical conditions cause continuous hypoperfusion (low blood flow) of the kidneys, leading to kidney atrophy (shrinking), loss of nephrons function, and chronic renal failure (CRF). These conditions include poor cardiac function, chronic liver failure, and atherosclerosis ("hardening") of the renal arteries. Each of these conditions induces ischemic nephropathy.

Post-Renal CRF

Interference with normal flow of urine produces backpressure within the kidneys, damages nephrons and leads to obstructive uropathy, a disease of the urinary tract. Abnormalities that may hamper urine flow and cause post-renal CRF include the following:

•  Bladder outlet obstruction due to an enlarged prostate gland or bladder stone.
•  Neurogenic bladder, an over distended bladder caused by impaired communicator nerve fibers from bladder to spinal cord.
•  Kidney stones in both ureters and tubes that pass urine from each kidney to bladder.
•  Obstruction of tubules, the end channels of renal nephrons.
•  Retroperitoneal fibrosis, formation of fiber like tissue behind peritoneum, membrane that lines abdominal cavity.
•  Vesicoureteral reflux (VUR), backward flow of urine from bladder into a ureter.

Renal CRF

Chronic renal failure caused by changes within kidneys, is called renal CRF, and is broadly categorized as follows :

•  Diabetic nephropathy, kidney disease associated with diabetes; the most common cause of CRF
•  Hypertension Nephrosclerosis, a condition that occurs with increased frequency in African Americans; the second leading cause of CRF
•  Chronic glomerular nephritis, a condition caused by diseases that affect glomeruli and bring about progressive dysfunction
•  Chronic interstitial nephritis, a condition caused by disorders that ultimately lead to progressive scarring of interstitium
•  Renal vascular CRF, large vessel abnormalities like renal artery stenosis   (narrowing of large arteries that supply kidneys)
•  Vasculitis, inflammation of small blood vessels
•  Cystic Kidney Disease – kidney disease distinguished by multiple cysts (lined cavities or sacs)
•  Hereditary diseases of kidney, such as Alport's syndrome (hereditary nephritis)

Role of Oxidative stress in Chronic Renal Failure

Oxidative stress defines an imbalance between formation of reactive oxygen species (ROS) and antioxidative defense mechanisms. In view of profound biological effects of ROS, in recent years, numerous clinical and experimental studies focused on detection of signs of oxidative stress in renal patients. There is good evidence indicating that uraemia in general is associated with enhanced oxidative stress and treatment of uraemic patients with haemodialysis or peritoneal dialysis is suggested to particularly contribute to oxidative stress and reduced antioxidant levels in these patients. The latter results from haemodialysis membrane-induced activation of macrophages on the surface of dialysis membranes during dialysis session. Loss or deficiency of antioxidant activity (e.g. vitamin E deficiency) could also contribute to enhanced oxidative stress in uraemia.

Biological effects of oxidative stress

Formation of ROS is part of the unspecific defense system of an organism against, for example, bacteria and other microbes. The ROS also affects cells of the host organism, in particular at sites of inflammation. The latter plays a role in a variety of renal diseases, such as glomerulone-phritis, acute or progressive renal failure, or tubulointerstitial nephritis, contributing to proteinuria. ROS contributes to the pathogenesis of ischaemia-reperfusion injury. Furthermore, due to their impact on cell cycle regulation, oxygen radicals contribute to hypertrophy of tubular cells.

Antioxidants alleviate brain dysfunction often seen with chronic kidney failure. Kidney failure is considered one of the most serious chronic disorders in worldwide. It is caused usually by diabetes, untreated high blood pressure, inflammation of the kidneys, inherited disorders and infections.

Currently, there is no cure; dialysis and kidney transplants are used to extend the lives of kidney failure patients.  Every year, chronic kidney failure has forced about 200,000 people to be on dialysis and about 87,000 people to have a kidney transplant. These treatments, however, do not improve the wide variety of neurological complications, common in kidney failure

"It's been documented that kidney failure patients suffer from neurological complications. Neurological disorders seen in kidney failure patients include slowed thought processes, fatigue, apathy, emotional instability, sleep disorders, hormone imbalance, forgetfulness, agitation and in severe cases, delirium, hallucinations, coma and convulsions. But the precise reason for the complications isn't known," said Dr. Nick Vaziri, Professor of Medicine and leading researcher. This study shows how free radicals and nitric oxide interact to produce oxidative stress and cause these neurological dysfunctions.

Role of Noni

Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. Although there are several enzyme systems within the body that scavenge free radicals, the principle micronutrient (vitamin) antioxidants are vitamin E, beta-carotene, and vitamin C. Additionally, selenium, a trace metal that is required for proper function of one of the body's antioxidant enzyme systems, is sometimes included in this category. The body cannot manufacture these micro-nutrients so they must be supplied in the diet. The easiest and most important way to stop free radical damage is to fortify our diet with antioxidant-rich foods. These provide natural protection from environmental and inherent free radical exposure. But that's not all. Antioxidants are important for many reasons, some of which are just beginning to be explained. For instance, flavonoids, found in fruits and vegetables, are the largest group of several thousand compounds belonging to antioxidant-rich polyphenol family. Flavonoids are further broken down into subclasses that you have likely heard of like anthocyanins, flavonols, flavones, flavanones and flavanols. Research showed very clearly that flavonoids have many health-promoting properties.

NONI works as a powerful antioxidant

Noni has the most powerful antioxidant properties. It protects our vital organs from deadly attack of free radicals. Noni contains all the vitamins, rich in beta-carotenes, abundant source of trace minerals, flavonoids, besides 150 + other most beneficial micronutrients.

Antioxidant property of NONI fights free radicals in three ways.

1. It prevents a free radical from forming.

2. It interrupts an oxidizing chain reaction to lessen effects of free radicals.

3. Antioxidant like Noni reduces free radical's impact.

Noni as an antioxidant neutralizes effects of free radicals, allowing the body to proper balance leading to health and well-being. Noni contains many different synergistic antioxidant nutrients, including the basic vitamins A, C & E. Drinking Noni every day helps combat the damaging effects of free radicals.

The natural integrity of Noni is only part of the reason for its effectiveness. There are two additional reasons contributing to NONI's effectiveness for a broad range of conditions :

1.  Unique Combinations of Substances

Noni has an impressive combination of ingredients. It has a rich complement of vitamins and minerals; including A, B vitamins (including the rare B-12), C, E, Iron, calcium, sodium, potassium, zinc and several trace minerals. It also has 17 of 20 amino acids. Terpenes, fungicides, adaptogens, glycosides, polysaccharides and other unique ingredients that even in small amounts can have significant physiological effects are found in Noni. It works like a food and acts like a medicine or herb without the side effects.

2.  Synergy of its Substances

Many known and unknown substances, come together in a way that supports needs of many of our internal systems, concurrently. As the word synergy implies, these substances work far better in combination than they do separately. Many of the ingredients in Noni are found in varying amounts in other foods or herbs. There seems to be no known food or herb with either the rich list of substances or the high amounts of key substances all put together in one super food. Noni aids the body's natural healing abilities.

NONI Works as a 'De-toxifier'

Our cells are made up of micro particles like neutrons, protons, cytoplasm and Golgi bodies which are genetically engineered to work well in a chemical-free environment. But because we live in a chemically polluted environment many types of toxins and pollutants are going into our body. They wrap the cells day by day and have formed multiple layers around cell walls, thus leading  closure or shrinking of pores of cell walls. Consequently, the inter cellular communication is prevented, the cells are damaged and they forget their purposes, they neither do their regular functions correctly nor efficiently.

NONI, being the powerful De-toxifier removes the toxic layers on the cell walls and it enlarges the pores of cell walls. This enlargement allows for larger chains of peptides (amino acids or proteins) to be admitted into the cell and to feed us better. If these chains are not used they become waste and this precious source of energy is lost by going to fat or being eliminated. But because of Noni's detoxification process, the cells resume their communications; are reminded of their purposes and they are rejuvenated with greater strength and life. Now the cells are able to assimilate the nutrients and medicines easily. They are strengthened and healed at their roots. This is the basis of NONI's cellular activity that causes the enhancement of efficacy of the medicine. Noni is a not a medicine. Noni works as a Protein Regular and Activator, Thanks to Dr. Ralph Heinicke who found out that Morinda citrifolia L. fruit is a rich resource of large molecules called Proxeronine (Prozair-o-neen) Proxeronine combines with enzymes in the body to form an essential substance known as Xeronine (zair-o neen). Once Xeronine is formed, it combines with many proteins in the body that requires Xeronine to function. Not all proteins, but many vital proteins, acting as hormones, antibodies and enzymes need Xeronine to carry out their duties.

Why is a Proxeronine rich supplement important in our diet ?

Some reasons include loss of micro nutrients from the soil and poor nutrition in our diet. Even illness, a highly active or stressful lifestyle and ageing, plays an increased demand on proteins. To meet these demands and keep the body healthy, we need to increase supply of Proxeronine by regularly drinking Noni. This helps to overcome low levels of Xeronine in our bodies and restores healthy protein assimilation.

NONI works as a Healthy and Immune System Promoter.

Current studies revealed  that Noni helps prompt a healthy immune system by either enhancing an already functioning system or by stimulating a sluggish one. In addition, as described earlier, Noni  fortifies and maintains cell structure. This can be accomplished by Noni acting as an adoptogen that can aid  "sick" cells in repairing themselves. A Cellular Food, Noni works at the Cellular level ! Works at the root of illness ! Works at the source, not with the symptoms. Noni contains health enhancing attributes that are antibacterial, anti-inflammatory, analgestic, anti congestive and has cancer-inhibiting compounds

Recommended Dosage

Divine Noni Concentrate

5ml 12 hourly 2 times in a day for 5 days. Then

5ml morning and 10ml evening for next days. Then

10ml morning and 10ml evening for next 10 days. Then

15ml morning and 15ml evening for next 8 months.