Juvenile Angiofibroma
Juvenile angiofibroma is a benign growth of back of nose or upper throat (nasopharynx). This tumor contains of many blood vessels. Juvenile angiofibroma is relatively uncommon. It typically is discovered in adolescent boys and is associated with nasal congestion, a visible nasal mass and nosebleeds (epistaxis). The tumor is locally invasive and capable of eroding bone.
Symptoms
- Nosebleeds (epistaxis)
- Frequent and repeated nasal congestion, difficulty in breathing through the nose
- Nasal discharge, usually blood tinged
- Hearing loss
- Prolonged bleeding, bruising easily – episodes are frequent or occur repeatedly (recurrent)
Role of Noni
Major components : Noni contains all the vitamins like vitamin A , vitamin B complex, vitamin C and vitamin E. It contains all the trace minerals. A number of major components are identified in the Noni plant like scopoletin, octoanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones (such as nordamnacanthal, morindone, rubiadin, and rubiadin-1-methyl ether, anthraquinone glycoside), sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, Alizarin, amino acids, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin, and a putative proxeronine.
Noni exhibits antiangiogenesis effects on the malignant cells
The tumor has the ability to develop its own blood vessels around to get their nutrition for growth by the process of angiogenesis. Many phytochemicals present in NONI like Damnacanthal, Alizarin, Limonene, Epigallocatechin gallate (EGCg) etc, just a few among the 150+ phytochemicals present in Noni that exhibit ANTIANGIOGENESIS effect on tumor cells. This inhibits growth of tumor cells and induces program cell death or apoptosis.
Epigallocatechin gallate (EGCg)
EGCg is a polyphenolic flavonoid antioxidant found in abundance in Noni. EGCg in Noni inhibits quinol oxidase (NOX) enzyme tumor activity thus helps in antiangiogenesis.
NOX enzymes are found in a variety of cell types and tissues where they react with oxygen to generate reactive oxygen species (ROS), the free radical forms of oxygen that damage the DNA of cell.
The ROS is involved in mutations and tissue damage in diseases like cancer and rheumatoid arthritis. Normal amounts of NOX production are important to regulate cell growth. It is generally inactive during normal cell division process on response to growth hormone stimulation but it is active in all the time in tumor’s cell and responsible for cell proliferation, cell motility, invasion and angiogenesis process, all of them prerequisites for tumor metastasis.
EGCg, a primary component of NONI inhibits the NOX activity of tumour cells. According to Dr. Morre’s experimental studies, it is found that EGCg in NONI inhibits NOX carcinogenesis activity but does not inhibit the NOX activity of healthy cells.
Recommended Dosage
Divine Noni Concentrate
5ml morning and 5ml evening for 3 days. Then
10ml morning and 10ml evening for next 3 days. Then
15ml morning and 15ml evening for next 8 months.
