Goiter
Toxic nodular goiter involves an enlarged thyroid gland that contains a small rounded mass or masses called nodules, which produce too much thyroid hormone. Toxic nodular goiter arises from a long-standing simple goiter and occurs most often in the elderly. Symptoms are those of hyperthyroidism, but the protruding eyeballs seen in Graves' disease do not occur. Risk factors include being female and over 60 years old. This disorder is never seen in children.
Symptoms
- Weight loss
- Increased appetite
- Nervousness
- Restlessness
- Heat intolerance
- Increased sweating
- Fatigue
- Muscle cramps
- Frequent bowel movements
- Menstrual irregularities (in women)
Signs and tests
A physical examination reveals single or multiple nodules in the thyroid. There may be a rapid heart rate.
- A thyroid scan shows elevated radioactive iodine uptake in the nodules.
- Serum TSH (thyroid stimulating hormone) is decreased.
- Serum thyroid hormone levels (T3, T4) are elevated.
Role of Noni in Goiter
The natural integrity of Noni is only part of the reason for its effectiveness. There are two additional reasons contribution to Noni's effectiveness for a broad range of conditions:
1. Unique Combinations of Substances
2. Synergy of its Substances
Noni in endocrine disturbances
Endocrine-disrupting chemicals (EDCs) produce a wide variety of endocrine-disruption effects, including developmental disorders, carcinogenicity and mutagenicity. One recent study demonstrated that about 94% of the 48 EDCs generated free radicals and that this free radical generation induced by EDCs might represent a common toxic mechanism of action of EDCs. In this context, it is proposed that EDCs may produce endocrine-disrupting effects including carcinogenicity via generation of free radicals, and thus the effects may be modulated or prevented by scavenging free radicals with antioxidants, like vitamins, curcumin, isoflavonoids, resveratrol and plant polysaccharides.
Noni contains all the antioxidant vitamins, many flavonoids, all trace minerals and thus acts as a powerful antioxidants.
Endogenous antioxidants and role of Noni : Human body has evolved with endogenous defense mechanisms to protect against free radical induced cell damage. Glutathione peroxidase, catalase and Superoxide dismutases are three primary antioxidant enzymes in our body, which involved in direct elimination of free radicals or reactive oxygen species from human body. They require micronutrients like selenium, iron, copper, zinc and manganese as cofactors for their formation and optimum catalytic and effective antioxidant activity. Noni contains all the trace minerals that help optimum catalytic activity of those three important antioxidant enzymes for an effective antioxidant defense mechanism.
Glutathione, ascorbic acid, alpha-tocopherol, beta-carotene, bilirubin, selenium, dihydrolipoic acid, reduced CoQ10, melatonin, uric acid etc., as a whole play a homoeostatic or protective role against ROS produced during normal cellular metabolism and after active oxidation insult. Noni contains all the above phyto chemicals and vitamins in abundant quantity. Glutathione (GSH) is the most significant component which directly quenches Reactive Oxygen Species (ROS) such as lipid peroxides and plays major role in xenobiotic metabolism. Glutathione is a tripeptide made up of amino acids gamma-glutamic acid, cysteine and glycine. Noni contains all those glutathione making amino acids in abundant quantity. Thus Noni increases the body's glutathione level. Noni stimulates more melatonin secretion from the pineal body. It also maintains ascorbate (vitamin C) and alpha-tocopherol (vitamin E), in their reduced form, which also exerts an antioxidant effect by quenching free radicals.
A number of other dietary antioxidants known as phytonutrients or phytochemicals that are being increasingly appreciated for their antioxidant activity. One example is flavonoids which are a group of polyphenolic compounds. They are responsible for the different brilliant colors such as blue, scarlet and orange. Noni contains 150 and above phytochemicals including all flavonoids. Flavonoids exhibit several biological effects such as antitumoural, anti-ischaemic, anti-allergic, anti-hepatotoxic, anti-ulcerative and anti inflammatory activities. These are also known to inhibit activities of several bad enzymes like lipoxygenase, cyclooxygenase, monooxygenase, xanthine oxidase, glutathione-S transferase, mitochondrial succino-oxidase and protein kinases. Many of the biological activities of flavonoids are attributed to their antioxidant properties and free radical scavenging capabilities. Noni is rich in many flavonoids.
Recommended Dosage
Divine Noni Concentrate
5ml morning and 5ml evening for 3 days. Then
10ml morning and 10ml evening for next 3 days. Then
15ml morning and 15ml evening for next 8 months.
