Frozen shoulder

Frozen Shoulder is the common term for adhesive capsulitis, an inflammatory condition that restricts motion in shoulder. The capsule of a shoulder joint includes the ligaments that attach the shoulder bones to each other. When inflammation occurs within the capsule, the shoulder bones are unable to freely move within the joint. Diabetes, shoulder trauma (including surgery), a history of open heart surgery, hyperthyroidism, and a history of cervical disk disease are all associated with an increased risk for this problem. Often, there is no known cause.

Symptoms

The main symptoms are pain and stiffness. In those with idiopathic frozen shoulder (frozen shoulder without an identifiable cause), pain is usually the first symptom. The patient usually does not want to move the arm. The lack of movement leads to stiffness, which is the second phase of the disease. The third phase, thawing, is when the motion and function of the shoulder slowly return.

Role of Noni in Frozen Shoulder

Noni has a broad range of health benefits against various diseases and complaints. Noni contains vitamin A, vitamin B complex, vitamin C, vitamin E. It contains all the trace minerals. A number of major components are identified in Noni plant such as scopoletin, octoanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones (nordamnacanthal, morindone, rubiadin, and rubiadin-1-methyl ether, anthraquinone glycoside), sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, Alizarin, amino acids, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin and a putative proxeronine

Cyclooxygenase (COX) enzyme and its role in inflammation

Pain, redness, heat and swelling which are the markers of inflammation, follow the release of prostaglandins. The non-steroidal anti-inflammatory drugs (NSAIDS) reduce prostaglandins by blocking an enzyme which helps to produce them, called cyclooxygenase (COX). There are actually two COX enzymes in the body. They are COX-1 and COX-2. COX-1 is called good COX enzyme, while COX-2 has earned the unflattering name as bad enzyme. COX1 is easily identifiable and is important in regulating cell function. COX2, on the other hand, is generally undetectable in most tissues, but increases to high levels during acute inflammation

The COX2 enzyme is largely responsible for causing pain and inflammation. Injury, disease and trauma cause COX2 enzyme to produce prostaglandins, which cause pain and inflammation. In contrast to the COX-2 enzyme, COX-1 enzyme is responsible for protecting body's stomach lining and kidneys. COX-2 is the key player in inflammation and pain.

NSAIDs decrease the body's production of both enzymes, thereby decreasing inflammation while at the same time causing harm to the stomach and its lining. The ideal situation would be to find a substance that inhibits only COX-2, but do not significantly affect COX-1.

Noni in pain and inflammatory condition

Noni is a selective COX-2 inhibitor. Researchers found that Noni was a selective inhibitor of COX-2 enzyme. In addition, the Noni did no damage to COX1 enzyme.

Role of Scopoletin in Noni in arthritis and inflammation

Another reason for Noni's pain fighting qualities stems from several of its constituents. Noni contains Scopoletin, which has anti inflammatory effects. Scopoletin is needed in body for smooth joint movement. It also produces anti-histamine effects.

Essential tremor is the most common form of abnormal tremor. Although the cause is unknown, new research shows that the part of the brain called the cerebellum does not appear to work correctly in patients with essential tremor. The cerebellum is the part of the brain that coordinates muscle movements.

Essential tremor is a relatively benign condition, affecting movement or voice quality, but with no other effects. It involves a rhythmic, moderately rapid tremor of voluntary muscles. Purposeful movements may make the tremors worse, while avoiding hand movements may make the tremors go away completely. People with essential tremors may have trouble holding or using small objects, such as silverware or a pen.

Over time, the tremors may affect the hands, arms, head, voice box, eyelids, or other muscles. An essential tremor rarely involves the legs or feet.

There are several different types of essential tremor, including young-onset essential tremor and essential tremor with head tremor. These types differ in their response to treatment. If an essential tremor occurs in more than one member of a family, it is called a familial tremor. It appears that genes may play a role in the development of essential tremors. Not only have the tremors been shown to be passed down through families, but an identical twin (who shares the same genes) of a person with essential tremor is twice as likely as a fraternal twin (who has different genes) to have essential tremor. Since some identical twins do not share this condition, environmental factors must also play a role. Essential tremors can occur at any age but are most common in people older than 65.

Symptoms

The Tremors

May be occasional (sporadic), temporary (episodic) or occurring at intervals (intermittent)
Occur at a rate of about 6 to 10 oscillations / second
May affect the head, hands, arms, eyelids, voice
Less commonly affect the legs and feet
May not affect both sides of the body equally
Worsen with voluntary movement or emotional stress
Disappear during sleep
Typically improve with alcohol

Role of Noni in Tremor

Noni has a broad range of health benefits for various diseases and complaints.

Major components Noni contains all the vitamins like vitamin A, vitamin B complex, vitamin C, vitamin E. It contains all the trace minerals. A number of major components are identified in the Noni plant such as scopoletin, octoanoic acid, potassium, vitamin C, terpenoids, alkaloids, anthraquinones (such as nordamnacanthal, morindone, rubiadin, and rubiadin-1-methyl ether, anthraquinone glycoside), sitosterol, carotene, vitamin A, flavone glycosides, linoleic acid, Alizarin, amino acids, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin and a putative proxeronine.

How Noni works ?

The natural integrity of Noni is only part of the reason for its effectiveness. There are two additional reasons contributing to Noni's effectiveness for a broad range of conditions:

Unique Combinations of Substances

For a fruit, Noni has an impressive combination of ingredients. It has a rich complement of vitamins and minerals; including vitamins A, B (including the rare B-12), C, E, Iron, calcium, sodium, potassium, zinc and several trace minerals. It also has 17 of 20 amino acids. Terpenes, fungicides, adaptogens, glycosides, polysaccharides and other unique ingredients that even in small amounts can have significant physiological effects can be found in Noni. Studies show that NONI stimulates the immune system, regulates proper cell function, increases the ability of cells to absorb and utilize nutrients, inhibits tumor growth and regenerates damaged cells. Probably the most unique ingredient is an alkaloid called xeronine. Xeronine has several important functions including regulating the many proteins in the body, activating inactive enzymes and improving cellular function. Noni also contains a substance called proxeronine, which can be stored in liver according to Dr. Ralph Heinecke. Proxeronine, in turn, can be used to make xeronine, as needed.

Synergy of its Substances

The many known, and even some of the unknown substances, come together in a way that supports the needs of many of our internal systems, concurrently. As the word synergy implies, these substances work far better in combination than they do separately. Many of the ingredients in Noni are found in varying amounts in other foods or herbs. There seems to be no known food or herb with either the rich list of substances or the high amounts of key substances all put together in one super food. Noni aids the body's natural healing abilities.

Antioxidant property of Noni

Endogenous antioxidants and role of Noni - Our body has evolved with endogenous defense mechanisms to protect against free radical induced cell damage. Glutathione peroxidase, catalase and Superoxide dismutases are three primary antioxidant enzymes in our body, which involved in direct elimination of free radicals or reactive oxygen species from our body. They require micronutrients such as selenium, iron, copper, zinc and manganese as cofactors for their formation and optimum catalytic and effective antioxidant activity. Noni contains all the trace minerals that help for optimum catalytic activity of those three important antioxidant enzymes for an effective antioxidant defense mechanism.

Glutathione, ascorbic acid, alpha-tocopherol, beta-carotene, bilirubin, selenium, dihydrolipoic acid, reduced CoQ10, melatonin, uric acid etc., as a whole play a homoeostatic or protective role against ROS produced during normal cellular metabolism and after active oxidation result. Noni contains all the above phyto chemicals and vitamins in abundant quantity. Glutathione (GSH) is the most significant component which directly quenches Reactive Oxygen Species (ROS) such as lipid peroxides and plays major role in xenobiotic metabolism. Glutathione is a tripeptide made up of the amino acids gamma-glutamic acid, cysteine, and glycine. Noni contains all those glutathione making amino acids in abundant number. Thus Noni increases the body's glutathione level. Noni stimulates more melatonin secretion from the pineal body. It also maintains ascorbate (vitamin C) and alpha-tocopherol (vitamin E), in their reduced form, which also exert an antioxidant effect by quenching free radicals.

Exogenous antioxidants : Contribution from Noni

A number of other dietary antioxidants known as phytonutrients or phytochemicals that are being increasingly appreciated for their antioxidant activity are present in Noni. One example is flavonoids which are a group of polyphenolic compounds. They are responsible for the different brilliant colors such as blue, scarlet and orange. Noni contains 150 above phytochemicals including all flavonoids. Flavonoids exhibit several biological effects such as antitumoural, anti-ischaemic, anti-allergic, anti-hepatotoxic, anti-ulcerative, and anti inflammatory activities. These are also known to inhibit the activities of several bad enzymes like lipoxygenase, cyclooxygenase, monooxygenase, xanthine oxidase, glutathione-S transferase, mitochondrial succino-oxidase and protein kinases. Many of the biological activities of flavonoids are attributed to their antioxidant properties and free radical scavenging capabilities. Noni is rich in many flavonoids.

Recommended Dosage

Divine Noni Concentrate

5ml morning and 5ml evening for 3 days. Then

10ml morning and 10ml evening for next 3 days. Then

15ml morning and 15ml evening for next 8 months.