Epidermolysis Bullosa
Epidermolysis bullosa is a group of inherited disorders in which skin blisters develop in response to minor injury. There are four main types of epidermolysis bullosa : Epidermolysis bullosa simplex, Junctional epidermolysis bullosa, Dystrophic epidermolysis bullosa and Hemidesmosomal epidermolysis bullosa.
Another rare type of epidermolysis bullosa, called epidermolysis bullosa acquisita, is an autoimmune disorder. This may be indistinguishable from another autoimmune skin disorder called mucous membrane pemphigoid.
Depending on the type present, epidermolysis bullosa varies in severity from minor blistering of the skin to a lethal form involving other organs. The condition generally starts at birth or soon after that. Epidermolysis bullosa acquisita, however, usually appears in adults over age 50, although it is reported in children. Also, mild cases of epidermolysis bullosa simplex remains undiagnosed until adulthood.
The classification of epidermolysis bullosa is complicated. Even within the main types mentioned, there are many different subtypes of this condition. For example, Weber-Cockayne is the most common form of epidermolysis bullosa simplex. This type involves blistering of the palms and soles and includes excessive sweating.
All of the different types of epidermolysis bullosa are generally inherited. Therefore, having a family history of the disease, especially an affected parent, is a risk factor. The inheritance pattern may be dominant or recessive. A dominant form means that an offspring can inherit the gene or trait from one affected parent. The recessive form means that both parents must carry a gene and transmit that gene to the offspring in order for the infant or child to be affected. The recessive forms of epidermolysis bullosa tend to be more severe.
The hallmark of these conditions is the formation of large, fluid-filled blisters that develop in response to minor trauma. Some infants may have large blisters at birth. Others start shortly after birth. Chafing (wearing away) of the skin, rubbing or even increased room temperature may cause blisters to form.
In severe forms, scarring after blister formation may cause deformities, fusion of the fingers and toes, and contracture deformities (for example, at the fingers, elbows and knees). If the mouth and esophagus are involved, blistering and scarring lead to feeding and swallowing difficulties. Secondary infection is common.
Symptoms
Symptoms depend on the type of epidermolysis bullosa, but can include:
- Blistering of the skin as a result of minor trauma or temperature change
- Blistering present at birth
- Nail loss or deformed nails
- Blistering in or around the mouth and throat, causing feeding difficulty or swallowing difficulty.
- Blistering around the eyes and nose
- A hoarse cry, cough, or other respiratory difficulties
- Dental abnormalities such as tooth decay
- Alopecia (hair loss)
- Milia (tiny white bumps or pimples)
For epidermolysis bullosa acquisita, there is an association with Crohn’s disease (an inflammatory bowel disease) and, possibly, lupus. Symptoms of these conditions may be present, therefore, in adults who present with this type of epidermolysis bullosa.
Role of Noni
Noni has a broad range of health benefits for various diseases and complaints.
Maternal and fetal malnutrition is a fundamental cause of genetic problems. It is very difficult to know for sure if a birth defect is the result of genetics or environmental factors. The mother represents half of a developing baby’s heredity, but almost all of the developing baby’s environment. Every single cell in a baby is the product of inherited DNA instruction. But every single cell in a baby is also the product of the mother’s diet. Ova (human eggs) are formed during the fetal stage of a female’s life. In other words, all of a woman’s own eggs are actually formed while she was developing inside her mother, before she herself was born. This means that what our grandmother ate significantly contributed to our anatomy. What looks to be purely a genetic problem may in fact be a largely a nutritional one.
The good news is that if nutrient deficiency can cause an illness, nutrient therapy may ameliorate, or even cure, that illness. Genes are “turned on or off” by one or more nutrients. This is important knowledge as we try to understand how individual differences affect our nutrient needs and tolerances. We need to know how what we eat affect the phenotypic expression of our own particular genotype.
The important interrelationship between food and the genes was first called the “genetotrophic concept” by Roger J. Williams, PhD. Dr. Williams, the discoverer of the B-vitamin pantothenic acid, explained in his scientific papers how existing biochemical birth defects may be effectively overcome with optimum nutrition. In genetotrophic diseases, genetic abnormality leads to nutritional disability. To compensate, the body requires the availability of larger than normal quantities of one or more nutrients for the affected gene to successfully express itself. For that particular person, normal dietary vitamin intakes are quite inadequate for normal function.
How Noni works ?
The natural integrity of Noni is only part of the reason for its effectiveness. There are two additional reasons contributing to Noni’s effectiveness for a broad range of conditions :
Unique Combinations of Substances
Synergy of its Substances
Recommended Dosage
Divine Noni Concentrate
5ml morning and 5ml evening for 3 days. Then
10ml morning and 10ml evening for next 3 days. Then
15ml morning and 15ml evening for next 8 months.
