Angiodysplasia

Angiodysplasia of the intestine is a condition of stretched and fragile blood vessels in the G.I.tract that results in occasional loss of blood from the gastrointestinal (GI) tract. The condition is mostly related to the aging and degeneration of blood vessels, and occurs in older adults. Angiodysplasia of the colon is not related to cancers or other diseases of blood vessels. It is different from diverticulosis, another very common cause of bleeding in older adults. There are several theories about angiodysplasia of the colon. The most likely is that normal contractions of the colon result in dilation (stretching) of colonic veins, venules and capillaries. The dilation becomes so severe that a small direct passage way develops between the artery and vein (arteriovenous fistula). It is in this area of colon wall that the patient is at risk for bleeding.

The symptoms vary. Often, in elderly patients, the symptoms are anaemia, weakness, fatigue and shortness of breath. There may not be any signs of bleeding directly from colon. Others may have occasional mild or severe bleeding episodes with bright red blood coming from rectum.

A few patients may have dark or black tarry stools. There is no pain associated with angiodysplasia.

Role of Noni

1.  Antioxidant property of Noni

A well accepted fact is the increasing incidence of diseases with advancing age. A plausible explanation for association of age and disease is based on implication of free radical reactions in the pathogenesis of several disorders. Free radical reactions produce progressive adverse changes that accumulate with age throughout the body. Such “normal” changes with age are relatively common to all. Superimposed on this common pattern are patterns influenced by genetics and environmental differences that modulate free radical damage. These are manifested as diseases at certain age determined by genetic and environmental factors. Cancer and atherosclerosis are two salient “free radical” diseases. Angiodysplastic lesion over G.I tract is also a free radical disease like the above two.

A natural powerful antioxidant helps to rectify to some extent to that condition. Noni is a powerful antioxidant. Noni contains all vitamins and are abudant with main antioxidant vitamins  vitamin E, vitamin C, and beta carotene. It also contains all trace minerals and is rich in all antioxidant minerals. Besides, Noni contains many bio flavonoids and 150 and above phytonutrients that make Noni a powerful antioxidant. Therefore, that patient of angiodyplastic lesion if taking Noni for a longer period may help to improve that degenerative condition of blood vessels developing angiodyspsia.

2. The xeronine in Noni

Collagen fibrils provide tensile strength to numerous tissues like skin, tendons, bones and blood vessels. Although flexible, collagen fibres offer a great resistance to any pulling force. Collagen fibres are fairly simple proteins and are made up of chains of amino acids. Amino acids are delivered from circulation to the cell called fibrocytes that manufacture collagen. The three important nutrients of collagen namely glycine, hydroxyproline and hydroxylysine are naturally present in Noni. With aging, this collagen simply becomes metabolically inert. It loses its responsiveness, flexibility, fluidity and strength. Thus the degenerative changes occur in blood vessels in angiodysplasia which may be the cause of metabolic inertness of collagen made up of proteins. According to Dr. Ralph Heinicke, Noni fruit contains a natural precursor for Xeronine that he named Proxeronine. Proxeronine is converted to the alkaloid Xeronine in the body by an enzyme he calls Proxeroninase. His hypothesis is that Xeronine modifies the molecular structure of proteins. Xeronine has a wide range of biological activities. Xeronine interacts with protein and makes it fold into its proper conformation. Result is a properly functioning protein. Whenever a problem arises in the cell due to a protein structural problem, Xeronine’s presence would be beneficial. His hypotheses explain why Noni helps in many health problems in different ways. Xeronine present in Noni helps angiodysplasia case origin from collagen inertness.

3. The immune enhancing power of Noni

Noni is a powerful immune enhancer and booster. Studies show that NONI stimulates the immune system, regulates proper cell function, increases ability of cells to absorb and utilize nutrients and regenerate damaged cells. Hence Noni is helpful in angiodysplasia. The natural integrity of Noni is only part of the reason for its effectiveness. There are two additional reasons contributing to NONI’s effectiveness for a broad range of conditions :

1. Unique Combination of Substances

2. Synergy of its Substances

The many known and unknown substances come together in a way that supports the needs of many of our internal systems, concurrently. As the word synergy implies, these substances work far better in combination than they do separately. Many of the ingredients in Noni are found in varying amounts in other foods or herbs. There seems to be no known food or herb with either the rich list of substances or high amounts of key substances all put together in one superfood. Noni aids the body’s natural healing abilities.

Hence the patient of “angiodysplasia of jejunum” if taking Noni for a longer period, it will not only help to improve his existing condition but also prevents from further damage.

Role of Noni in Ischemic Heart Disease (IHD)

Heart attack is the number-one cause of death not only in India but also in whole world. Our fastidious life style, rich diet habits, physical inactivity and stressfull mental condition are the predisposing factors of various cardiac problems and heart attacks. The high rise of cholesterol in our blood is one of the causes of many cardiac problems and heart attacks. The oily fatty food, ghee and fried foods have become a habit in our daily routine diet. It all causes the rise of cholesterol in our blood and plays the main role in generating various heart diseases like coronary artery diseases, ischemic heart diseases, atherosclerotic plaques in artery, unstable angina pain etc. 

Cholesterol is of two types  HDL (high density lipoprotein) cholesterol and LDL (low density lipoprotein) cholesterol. Among them HDL cholesterol is good for our body. But LDL cholesterol is named as bad cholesterol and this is the one which is the route cause of coronary artery diseases, angina pain, and atherosclerosis of artery etc. But LDL cholesterol is not really bad in its native form because God did not make a mistake when he created it. Native LDL cholesterol is good. In fact, it is essential for building good cell membrane, other cell parts and many different hormones that our body needs. Problems begin when native LDL cholesterols are oxidized by free radicals in our body and make them harmful cholesterol. The high environmental pollutions, stressful life style and good nutrients depleted diet are main causes of over production of free radicals in our body. Those free radicals play the main role to oxidize LDL cholesterol and make it harmful to body.

The inner layer of our artery is called endothelium which is an extremely sensitive lining vulnerable to even the slightest irritation. Oxidized cholesterol and excessive free radicals cause the oxidative stress that injures the endothelium. Our body has a defense system designed to protect this endothelium of artery. In the events of injury, our body respondes by sending WBC (mainly monocytes) to eliminate harmful oxidized LDL cholesterol. Here the defense team of monocytes starts gobbling up the enemy to minimize irritation to endothelium. If this response process is successful, the problem is over and the lining of the artery will be repaired. But this is not what usually happens. Monocytes continue to gather delinquent oxidized LDL cholesterol, but they do not let any out. Hence the monocytes get crammed so full of oxidized LDL cholesterol(fat) that it becomes a foam cell and looks like a ball of fat. This foam cells then attach itself to the lining of the artery and eventually forms the initial defect of hardening of arteries,  called fatty streak. The fatty streak is an inflammatory lesion. This leads to form a plaque. It is the initial step in the process called atherosclerosis. The atherosclerotic plaque goes on increasing in size and consequently makes the artery narrow inside to pass blood flow. The entire process is a vicious cycle. Not only there is build up of plaque, but there is also thickening of artery. Normally the layer of endothelium functions well by releasing an important product called nitrous oxide (NO). During this inflammatory response, however, the appropriate release of nitrous oxide is blocked from the endothelium, causing endothelium to function poorly. This in turn causes the platelets of blood to adhere to the plaque and the artery around the plaque to go into spasm. About 50% of heart attacks are the rapture of one of these plaques and the clot that forms around a ruptured plaque. A situation such as this causes acute and abrupt total closure of this artery which blocks the blood flow to that part of the heart. Oxidative stress may also cause break down of these plaques, which eventually lead to their rupture.Arteries keep narrowing to the point that they become occluded. These patients have usually symptoms of chest pain called unstable angina.  

To neutralize notorious activity of those free radicals to convert the native LDL cholesterol to harmful LDL cholesterol, it requires some powerful antioxidants. Those antioxidants not only neutralize the effect of free radicals on the vessels cells but also to other cells.

Divine Noni juice found to be high in Antioxidants

NONI has the powerful antioxidant properties that help to neutralize free radicals role of oxidation of the native LDL cholesterol to harmful LDL cholesterol and thus protects the arterial endothelial lining from injury and future developing atheromatous plaque. The main antioxidants are vitamins A, E and C, beta-carotene, glutathione, bioflavonoid, selenium, zinc, CoQ10 (ubiquinone) and various phyto-chemicals. NONI is rich in Vit A, Beta carotene, Vit E, C, glutathione, bioflavonoid, selenium, zinc and many more essential phytochemicals. Melatonin, a hormone produced by pineal gland, is also a potent antioxidant. NONI stimulates more melatonin release from the pineal gland.

Noni and Nitric oxide : their role in preventing arterial cells damage

Normally the layer of endothelium functions well by releasing an important product called nitrous oxide (NO). During this inflammatory response of forming the plaques, however, the appropriate release of nitrous oxide is blocked from the endothelium, causing endothelium to function poorly. NONI helps to proper production of nitrous oxide in our body and thus helps endothelium to function smoothly.

Noni promotes the cellular growth

In addition to the antioxidant activity in Noni, Dr. Ralph Heinicke, has pinpointed one constituent in Noni that he believes is responsible for the Juice’s ability to promote cellular growth. These are parts of his postulated xeronine system, which consists of proxeronine, proxeroninase and xeronine.

The xeronine theory, which is based on much of Dr. Heinicke’s work, postulates that once in the body, proxeronine travels to specific parts of cells, like the mitochondria, microsomes, Golgi apparatus, reticuloendothelium and electron transport system. Within the cell, these components communicate with each other (intracellular) and with other cells (intercellular). This communication between cells works according to theories of several Nobel Prize winning doctors.

Recommended Dosage

Divine Noni Concentrate

5ml morning and 5ml evening for 3 days. Then

10ml morning and 10ml evening for next 3 days. Then

15ml morning and 15ml evening for next 15 days. Then

20ml morning and 20ml evening for next 8 months.